18Jun
Bisakah saya bermain slot online tanpa mengunduh perangkat lunak apa pun?

Bisakah saya bermain slot online tanpa mengunduh

Anda mungkin bertanya-tanya apakah Anda bisa bermain slot online tanpa harus mengunduh perangkat lunak apa pun. Jawabannya adalah ya, Anda bisa. Permainan slot online modern biasanya didukung oleh teknologi HTML5, yang memungkinkan pemain untuk memainkan game langsung di browser web mereka tanpa perlu mengunduh atau menginstal perangkat lunak tambahan.

Ini adalah berita baik bagi mereka yang tidak ingin repot-repot mengunduh perangkat lunak tambahan atau mungkin khawatir tentang risiko keamanan yang terkait dengan mengunduh file yang tidak dikenal. Dengan bermain langsung di browser web, Anda dapat mengakses berbagai permainan slot online tanpa perlu menginstal apa pun di perangkat Anda.

Bermain Slot online tanpa mengunduh perangkat lunak juga memungkinkan fleksibilitas yang lebih besar. Anda dapat mengakses permainan favorit Anda dari berbagai perangkat, termasuk komputer desktop, laptop, tablet, atau ponsel pintar, asalkan perangkat tersebut terhubung ke internet dan memiliki browser web yang kompatibel.

Bisakah saya bermain slot online tanpa mengunduh perangkat lunak apa pun?

Selain itu, bermain langsung di browser web juga dapat menghemat ruang penyimpanan di perangkat Anda. Mengunduh dan menginstal perangkat lunak tambahan untuk bermain slot online bisa memakan banyak ruang, terutama jika Anda memiliki ruang penyimpanan terbatas di perangkat Anda. Dengan bermain langsung di browser, Anda tidak perlu khawatir tentang hal ini.

Namun, meskipun Anda bisa bermain slot online tanpa mengunduh perangkat lunak, ada beberapa hal yang perlu Anda pertimbangkan. Pertama, pastikan Anda memiliki koneksi internet yang stabil dan andal. Koneksi yang lambat atau tidak stabil dapat mengganggu pengalaman bermain Anda dan bahkan menyebabkan gangguan saat memutar gulungan.

Selain itu, beberapa platform atau game mungkin menawarkan opsi untuk mengunduh perangkat lunak klien jika Anda lebih suka bermain dengan cara itu. Beberapa pemain mungkin menganggap bahwa bermain dengan perangkat lunak klien dapat memberikan pengalaman yang lebih mulus atau fitur tambahan yang tidak tersedia saat bermain langsung di browser.

Namun, penting untuk diingat bahwa mengunduh perangkat lunak tambahan juga dapat meningkatkan risiko keamanan. Pastikan Anda hanya mengunduh perangkat lunak dari sumber yang tepercaya dan pastikan untuk memverifikasi keamanan perangkat lunak sebelum menginstalnya.

Secara keseluruhan, bermain slot online tanpa mengunduh perangkat lunak adalah pilihan yang nyaman dan mudah diakses bagi banyak pemain. Dengan teknologi HTML5 yang memungkinkan permainan langsung di browser web, Anda dapat menikmati berbagai permainan slot online tanpa harus repot-repot mengunduh atau menginstal perangkat lunak tambahan. Namun, pastikan Anda memiliki koneksi internet yang stabil dan aman untuk pengalaman bermain yang optimal.
17Oct
Google Ads API v18 launches with new features for developers

Google announced the release of version 18 of its Google Ads API, introducing several new features and improvements for developers.

Key updates:

  1. Optimized budget suggestions: New GenerateRecommendations feature for Performance Max and Search campaigns
  2. Performance Max insights: New performance_max_placement_view report for querying placement-specific data
  3. Flexible search settings: Replaced summary_row_setting and return_total_results_count with more customizable search_settings
  4. Enhanced segmentation: New segments for hotel and search campaign reports based on specific destinations
  5. Travel Feed support: Added new click and asset types for Search Ads
  6. Partnership ads: New DataLinkService.CreateDataLink for linking Google Ads accounts to creator videos
  7. Content performance metrics: New content_criterion_view for Display, Demand Gen, and Video campaigns

Why we care. These API updates enhance tools for optimizing campaigns and analyzing performance across different campaign types. New features like budget suggestions for Performance Max and Search campaigns, placement-specific data insights, and flexible search settings provide more granular control.

Between the lines. These updates reflect Google’s focus on improving performance tracking, optimization capabilities, and cross-platform integration.

What’s next:

  • Updated client libraries and code examples will be published next week
  • Developers will need to upgrade their client libraries and code to access v18 features

The bottom line. Google Ads API v18 offers developers more granular control and insights, potentially leading to more effective ad campaigns and better ROI for advertisers.

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About the author

Anu Adegbola

Anu Adegbola has been Paid Media Editor of Search Engine Land since 2024. She covers paid search, paid social, retail media, video and more.

In 2008, Anu’s career started with

 delivering digital marketing campaigns (mostly but not exclusively Paid Search) by building strategies, maximising ROI, automating repetitive processes and bringing efficiency from every part of marketing departments through inspiring leadership both on agency, client and marketing tech side.

 

Outside editing Search Engine Land article she is the founder of PPC networking event – PPC Live and host of weekly podcast PPCChat Roundup.

 

She is also an international speaker with some of the stages she has presented on being SMX (US), SMX (Munich), Friends of Search (Amsterdam), brightonSEO, The Marketing Meetup, HeroConf (PPC Hero), SearchLove, BiddableWorld, SESLondon, PPC Chat Live, AdWorld Experience (Bologna) and more.
17Oct
Harris Backs Slashing Medical Debt. Trump’s ‘Concepts’ Worry Advocates.
Noam N. Levey

Patient and consumer advocates are looking to Kamala Harris to accelerate federal efforts to help people struggling with medical debt if she prevails in next month’s presidential election.

And they see the vice president and Democratic nominee as the best hope for preserving Americans’ access to health insurance. Comprehensive coverage that limits patients’ out-of-pocket costs offers the best defense against going into debt, experts say.

The Biden administration has expanded financial protections for patients, including a landmark proposal by the Consumer Financial Protection Bureau to remove medical debt from consumer credit reports.

In 2022, President Joe Biden also signed the Inflation Reduction Act, which limits how much Medicare enrollees must pay out-of-pocket for prescription drugs, including a $35-a-month cap on insulin. And in statehouses across the country, Democrats and Republicans have been quietly working together to enact laws to rein in debt collectors.

But advocates say the federal government could do more to address a problem that burdens 100 million Americans, forcing many to take on extra work, give up their homes, and cut spending on food and other essentials.

“Biden and Harris have done more to tackle the medical debt crisis in this country than any other administration,” said Mona Shah, senior director of policy and strategy at Community Catalyst, a nonprofit that has led national efforts to strengthen protections against medical debt. “But there is more that needs to be done and should be a top priority for the next Congress and administration.”

At the same time, patient advocates fear that if former President Donald Trump wins a second term, he will weaken insurance protections by allowing states to cut their Medicaid programs or by scaling back federal aid to help Americans buy health insurance. That would put millions of people at greater risk of sinking into debt if they get sick.

In his first term, Trump and congressional Republicans in 2017 tried to repeal the Affordable Care Act, a move that independent analysts concluded would have stripped health coverage from millions of Americans and driven up costs for people with preexisting medical conditions, such as diabetes and cancer.

Trump and his GOP allies continue to attack the ACA, and the former president has said he wants to roll back the Inflation Reduction Act, which also includes aid to help low- and middle-income Americans buy health insurance.

“People will face a wave of medical debt from paying premiums and prescription drug prices,” said Anthony Wright, executive director of Families USA, a consumer group that has backed federal health protections. “Patients and the public should be concerned.”

The Trump campaign did not respond to inquiries about its health care agenda. And the former president doesn’t typically discuss health care or medical debt on the campaign trail, though he said at last month’s debate he had “concepts of a plan” to improve the ACA. Trump hasn’t offered specifics.

Harris has repeatedly pledged to protect the ACA and renew expanded subsidies for monthly insurance premiums created by the Inflation Reduction Act. That aid is slated to expire next year.

The vice president has also voiced support for more government spending to buy and retire old medical debts for patients. In recent years, a number of states and cities have purchased medical debt on behalf of their residents.

These efforts have relieved debt for hundreds of thousands of people, though many patient and consumer advocates say retiring old debt is at best a short-term solution, as patients will continue to run up bills they cannot pay without more substantive action.

“It’s a boat with a hole in it,” said Katie Berge, a lobbyist for the Leukemia & Lymphoma Society. The patient group was among more than 50 organizations that last year sent letters to the Biden administration urging federal agencies to take more aggressive steps to protect Americans from medical debt.

“Medical debt is no longer a niche issue,” said Kirsten Sloan, who works on federal policy for the American Cancer Society’s Cancer Action Network. “It is key to the economic well-being of millions of Americans.”

The Consumer Financial Protection Bureau is developing regulations that would bar medical bills from consumer credit reports, which would boost credit scores and make it easier for millions of Americans to rent an apartment, get a job, or secure a car loan.

Harris, who has called medical debt “critical to the financial health and well-being of millions of Americans,” enthusiastically backed the proposed rule. “No one should be denied access to economic opportunity simply because they experienced a medical emergency,” she said in June.

Harris’ running mate, Minnesota Gov. Tim Walz, who has said his own family struggled with medical debt when he was young, signed a state law in June cracking down on debt collection.

CFPB officials said the regulations would be finalized early next year. Trump hasn’t indicated if he’d follow through on the medical debt protections. In his first term, the CFPB did little to address medical debt, and congressional Republicans have long criticized the regulatory agency.

If Harris prevails, many consumer groups want the CFPB to crack down even further, including tightening oversight of medical credit cards and other financial products that hospitals and other medical providers have started pushing on patients. These loans lock people into interest payments on top of their medical debt.

“We are seeing a variety of new medical financial products,” said April Kuehnhoff, a senior attorney at the National Consumer Law Center. “These can raise new concerns about consumer protections, and it is critical for the CFPB and other regulators to monitor these companies.”

Some advocates want other federal agencies to get involved, as well.

This includes the mammoth Health and Human Services department, which controls hundreds of billions of dollars through the Medicare and Medicaid programs. That money gives the federal government enormous leverage over hospitals and other medical providers.

Thus far, the Biden administration hasn’t used that leverage to tackle medical debt.

But in a potential preview of future actions, state leaders in North Carolina recently won federal approval for a medical debt initiative that will make hospitals take steps to alleviate patient debts in exchange for government aid. Harris praised the initiative.

KFF Health News is a national newsroom that produces in-depth journalism about health issues and is one of the core operating programs at KFF—an independent source of health policy research, polling, and journalism. Learn more about KFF.

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This story can be republished for free (details).
17Oct
Amazon’s New Full-Color Kindle Could Be A Game Changer For Comic Books

Amazon has revealed five new Kindles, including its first full-color e-ink tablet. The Kindle Colorsoft is a brand-new addition to the lineup, and it’s a potential game changer for fans of comic books and graphic novels. You can already read digital comics on any Kindle reader, but unless it has black-and-white illustrations, you lose a key component of the story. If the Kindle Colorsoft works well, you will be able to read all of your favorite full-color comics, graphic novels, and manga as intended, with the inherit benefits of an e-ink display. It releases October 30 and is available to preorder now for $280.

The Kindle Colorsoft sounds even more appealing when you consider Amazon’s Comixology Unlimited subscription service. Comixology Unlimited offers over 45,000 comics, graphic novels, and manga for $10 per month (after a free 30-day trial). The catalog includes comics and graphic novels published by Marvel, DC, Dark Horse, Image, and other leaders in the visual storytelling medium. Kindle Unlimited also has graphic novels and manga, but Amazon’s $12/month flagship reading subscription service has a much larger focus on novels.

The Kindle Colorsoft releases October 30 and is available to preorder now for $280. We’ve rounded up all five of the new Kindles below, including the updated Kindle Scribe with improved note-taking features, a faster version of the ever-popular Kindle Paperwhite in models geared for adults and kids, and an upgraded entry-level Kindle.

Quick look: Amazon’s All-New Kindles

  • Preorder Now
  • Available Now

$280 | Save 20% with Eligible Trade-In | Releases October 30

The Kindle Colorsoft has a 7-inch full-color display that lasts up to eight weeks on a full charge, which is pretty remarkable for a color e-ink tablet. Designed to be used anywhere, the Colorsoft’s front light will automatically adjust to your surroundings. The high-contrast screen has built-in anti-glare technology to help create the Kindle’s signature paper-like reading experience, just with a full color palette this time around. While reading, you can highlight passages in color, which sounds like a nice little benefit for those who regularly like to revisit to share their favorite sentences.

Amazon has labeled the launch-model Colorsoft a “Signature Edition.” This may sound a bit confusing since it’s the only model available at launch, but Kindle Signature Editions offer a handful of upgrades versus lower-priced models: support for wireless charging, auto-adjusting front light, no ads, and 32GB of storage. Signature Editions also have metallic chassises. The Metallic Black Colorsoft checks all of the Signature Edition boxes.

Amazon says it’s totally safe to read in the bathtub or the pool, as the Colorsoft has an IPX8 water resistance rating. In lab tests, the Colorsoft still functioned after being immersed in 6.5 feet (2 meters) of fresh water for up to 60 minutes. You probably won’t want to bring the Kindle with you in ocean, though, as it’s only graded for three minutes of immersion at less than 0.8 feet (0.25 meters) of depth.

As mentioned, the Colorsoft is especially exciting for fans of comic books, graphic novels, and manga. Being able to read your favorite graphic novels in color on a paper-like display could bring those who have wanted to switch to digital but weren’t keen on the idea of looking at black-and-white illustrations into the ereader community.

At $280, the Colorsoft is cheaper than the Scribe but a good bit pricier than the Paperwhite. Amazon is running one of its generous trade-in promotions for existing Amazon device owners that can save you some serious cash. Trade-in values for your old devices vary, but what doesn’t change is the 20% discount on the Colorsoft. You’ll automatically save $56 plus however much you get for your old device. Click the “Save 20% with Trade-in” banner below the price to instantly see trade-in values for eligible devices. It doesn’t even need to be a Kindle. Other devices, including cheap Fire TV Sticks, can get you the 20%-off deal.

Amazon is also offering a deal on the Kindle Colorsoft Essentials Bundle, which comes with a plant-based leather cover and a wireless charging dock/stand for $328. You’re saving $35 by purchasing the bundle compared to buying the Colorsoft and both accessories separately. Cases are available to purchase separately, too. Amazon has fabric protective covers in three color options for $37, while the leatherette covers are $43. That means you’d spend $317 or $323 for the Colorsoft and one of the cases. The Kindle Colorsoft Essentials Bundle is probably the way to go here, as you’ll only spend $5-$11 more to get the charging stand thrown in, too.

Color e-ink has become a trend over the past year. Kobo, Amazon’s biggest competitor, released its own full-color e-ink reader in April. The Kobo Libra Colour has a 7-inch full-color display and 32GB of storage for $220. But switching between brands after years of use is tough, as Amazon and Kobo have unique digital storefronts and file formats. You can’t read Kindle ebooks on Kobo devices and vice-versa.

Most of the color e-ink tablets available now are more comparable to the Kindle Scribe as hybrid readers, note-taking, and productivity devices. For instance, Android e-ink tablet manufacturer Boox has released a few different full-color options, including the 7.8-inch Boox Tab Mini C for $400, the 10.3-inch Note Air 3 C, and the 10.3-inch Tab Ultra C Pro for productivity for $650.

And then there’s reMarkable, the manufacturer behind the most popular note-taking e-ink tablet not made by Amazon, released its own full-color tablet in September. The $629 reMarkable Paper Pro has an 11.8-inch display and is designed to replicate the experience of writing in a notebook.

Perhaps the next iteration of the Kindle Scribe will join the color e-ink party, too. For now, here’s what’s new with the Kindle Scribe and Amazon’s other black-and-white ereaders.

All of the new Kindles are eligible for Amazon’s 20%-off trade-in promotion.

Starting at $400 | Releases December 4

The updated Kindle Scribe now features new white borders, an updated screen with a paper-like texture for an improved writing experience, and a new Active Canvas feature that lets you write notes directly in your books. It comes bundled with the Premium Pen so you can draw, doodle, or jot down reminders during a meeting. It’s large 10.2-inch display is a good size for both reading or writing, and you can even share your files via email if you want to access them off your tablet.

The Kindle Scribe starts at $400 and is available in three different storage configurations: 16GB, 32GB, and 64GB. All three capacities can be purchased with a Tungsten chassis, and the 64GB is also available in Metallic Jade.

Multiple Kindle Scribe Essential Bundles are eligible for preorder discounts. For the 16GB model, the Essentials Bundle with a plant-based leather folio and AC adapter costs $435. Official Kindle Scribe cases cost more than $35, so if you preorder this one, it’d be a good idea to opt for one of the bundles. You can also get a bundle with a premium, natural leather folio starting at $460.

Starting at $160 | Available Now

This is the speediest Kindle on the market, as Amazon says it’ll get you 25% faster page turns than the previous generation. It also benefits from the highest contrast ratio in the Kindle lineup, which should result in crisper images and text. You’ll get a 7-inch display, 16GB storage, and up to three months of battery life, so you won’t have to worry about forgetting your charger when going on vacation.

It’s sold in three different colors and is available now. Prices start at $160 for the model with ads on the lockscreen. You can purchase the Kindle Paperwhite Essentials Bundle with a fabric cover and power adapter for $197. For $202, the Paperwhite Essentials Bundle comes with the leatherette case.

The new Kindle Paperwhite has the same form factor as the Colorsoft, so the two case options are the same: fabric for $37, leatherette for $43.

$110 | Available Now

The standard Kindle has also been upgraded, and it’s the most compact Kindle yet. It clocks at just 158 grams, and its 6-inch screen should make it easy to slip into a backpack or purse without taking up much space. It also benefits from a brighter front light, up to six weeks of battery life, and 16GB storage space.

$180 | Available Now

This version of the new Paperwhite comes with a durable cover to help protect it from the inevitable drops and scratches it’ll endure when placed in the hands of a young reader. You’ll also get a two-year worry-free guarantee and six months of Amazon Kids+ ($36 value), unlocking thousands of children’s books. Coupled with the included case, the new Paperwhite Kids reader is valued at $242.
17Oct
Fearful memories of others seen in mouse brain

How do we distinguish threat from safety? It’s a question important not just in our daily lives, but for human disorders linked with fear of others, such as social anxiety or post-traumatic stress disorder (PTSD). A microscope image, from the laboratory of Steven A. Siegelbaum, PhD, at Columbia’s Zuckerman Institute, displays a powerful technique scientists used to help us find an answer.

The scientists were investigating the hippocampus, a brain area that plays a key role in memory in humans and mice. Specifically, they focused on the CA2 region, which is significant for social memory, the ability to remember other individuals, and the CA1 region, which is important for remembering places.

In this new study, the researchers for the first time reveal that CA1 and CA2 respectively encode the locations and individuals linked with a threatening experience. The results show that, beyond simply recognizing individuals, CA2 helps record more complex aspects of social memory: in this case, whether another individual is safe or risky. The scientists published their findings on October 15 in the journal Nature Neuroscience.

“It’s vital to all species that live in social communities, including mice and humans, to have social memories that can help one avoid future experiences with others that might prove harmful while keeping ourselves open to individuals who may be beneficial,” saidPegah Kassraian, PhD, a postdoctoral research fellow in the Siegelbaum lab and lead author of the new study. “Fearful memories are important for survival and help to keep us safe.”

To investigate where fearful social memories originate in the brain, Dr. Kassraian and her colleagues gave individual mice a choice. They could scamper to one place, meet another mouse that was unknown to them, and receive a mild foot shock (much like a static electricity zap people might get after walking on a carpet and touching a doorknob). Scurrying in the opposite direction to meet a different stranger was safe. Normally, the mice quickly learned to avoid the strangers and locations that were associated with the shocks, and these memories lasted for at least 24 hours.

To determine where in the hippocampus these memories were stored, the researchers genetically altered the mice to enable them to selectively suppress the CA1 or CA2 regions. Surprisingly, turning off each region had very different effects. When the scientists silenced CA1, the mice could no longer remember where they were zapped, but they could still remember which stranger was associated with the threat. When they silenced CA2, the mice remembered where they were shocked, but became indiscriminately afraid of both strangers they met.

These new findings reveal that CA2 helps mice remember whether past encounters with others were threatening or safe. The results also are consistent with prior research detailing how CA1 is home to place cells, which encode locations.

Previous research has implicated CA2 in various neuropsychiatric conditions such as schizophrenia and autism. The new study suggests that further investigating CA2 might help scientists better understand social anxiety, post-traumatic stress disorder and other conditions that can lead to social withdrawal.

“It’s possible that social withdrawal symptoms are related to an inability to discriminate between who is a threat and who is not,” said Dr. Siegelbaum, who is also a professor and chair of the department of neuroscience at Columbia’s Vagelos College of Physicians and Surgeons. “Targeting CA2 could be a useful way of diagnosing or treating disorders linked with a fear of others.”

The paper, “The hippocampal CA2 region discriminates social threat from social safety,” was published online in Nature Neuroscience on October 15, 2024.

The full list of authors includes Pegah Kassraian, Shivani K. Bigler, Diana M. Gilly, Neilesh Shrotri, Anastasia Barnett, Heon-Jin Lee, W. Scott Young, and Steven A. Siegelbaum.

The authors report no conflicts of interest.
17Oct
Nita Ambani, Alia Bhatt’s hairstylist reveals if a haircut can ‘magically’ fix damage. Watch video | Health

Oct 17, 2024 02:15 PM IST

From using heat protection before using heat on hair to taking care of scalp health, here are a few tips to maintain healthy hair.

Split ends, damaged hair, rough hair quality – all of these problems have only one solution for most people– get a chop. However, cutting the hair may not be enough to fix the damage to the hair. Amit Thakur, hairstylist to many celebrities, including Nita Ambani, Priyanka Chopra, Alia Bhatt and Katrina Kaif, shared an informative reel on his Instagram profile and spoke of the need for a proper hair care routine to improve hair quality.

“Haircuts don’t fix damage,” wrote hairstylist Amit Thakur.

“Haircuts don’t fix damage, then what does,” read an excerpt from Amit Thakur’s Instagram post. Amit started his video by pointing out that no matter what the hair problem is, we address it by cutting the hair. However, that cannot address hair damage completely. Haircuts ensure that the damaged ends of the hair are removed – but it fails to address the root cause of hair damage.

ALSO READ: Festive tips from Deepika Padukone’s hairstylist: 6 hair care hacks to steal the spotlight this Diwali, Christmas

Hair is not a living cell:

Amit Thakur mentioned that once the hair is out of the follicle, it is not a living cell. Instead, it is a delicate fabric thread that needs constant care and nurturing. For that, we need to understand the elasticity, strength and shine of the hair and incorporate a healthy haircare routine.

ALSO READ: Heatwave hair care: Tips and tricks for managing your mane in summer

How to take care of your hair?

Amit Thakur mentioned that it is important to have a regular haircare routine that can prevent damage to hair. It is essential to be mindful of not using very high temperature on hair, as it can damage the hair completely. However, often we may need to use heat on hair – in such cases, the hairstylist mentioned that heat protection should be used. From mid-hair to the ends, heat protection and repair products should be thoroughly applied.

While we take care of hair, we should not forget scalp health. It is important to take care of scalp health and ensure that it is equally healthy and nice.

Disclaimer: This article is for informational purposes only and not a substitute for professional medical advice. Always seek the advice of your doctor with any questions about a medical condition.

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17Oct
Wave sees RNA editing validation in early trial results

Clinical trial results released by Wave Life Sciences Wednesday appear to provide early validation for the company’s newest drugmaking technology as well as a burgeoning field of genetic medicine, RNA editing.

The data are from just two patients, the first treated in a Wave study of the biotechnology firm’s medicine for an inherited lung and liver disease called alpha-1 antitrypsin deficiency, or AATD. Still, Wave claims the data show convincing evidence its medicine successfully edited the messenger molecules cells use to turn DNA blueprints into proteins.

According to the company, this kind of effect hasn’t before been demonstrated in clinical testing. “Achieving the first-ever therapeutic RNA editing in humans is a significant milestone for our organization, for our GSK collaboration, and for the entire oligonucleotide field,” said Wave CEO Paul Bolno in a statement.

Wave’s medicine is built from a strand of nucleic acid known as an oligonucleotide. Delivered into the body’s cells via a type of sugar molecule, the oligonucleotide recruits enzymes known as ADAR to change single bases on messenger RNA. This could allow Wave to correct garbled instructions for making proteins in people with genetic diseases like AATD. In theory, it could also sidestep some of the risks inherent to permanently altering DNA with drugmaking approaches like CRISPR gene editing.

The data Wave reported Wednesday indicate that, at least in the first two patients, the company’s treatment worked as intended. Both patients have a form of AATD which means their bodies don’t produce wild-type AAT protein. But, after treatment, researchers measured significant increases in this protein, as early as the third day following and through about two months of follow-up.

Total AAT protein levels reached, on average, 10.8 micromolars in blood plasma concentration by day 15 after treatment, which Wave said meets the threshold set by regulators for approval of AAT augmentation therapies.

There were no serious side effects and all adverse events in this study, as well as another in healthy volunteers, have been mild to moderate in nature, Wave said.

While preliminary, Wave’s results look to be a step forward for RNA editing, which has recently drawn significant investment from biotech and pharmaceutical companies alike.

Because RNA molecules degrade quickly, the effects of an RNA editing treatment are temporary. Developers claim this will help avoid the risk of long-term harm that might result from wayward snips to DNA via gene editing. They also contend RNA editing allows for more precise tweaking of protein expression and gives them the ability to administer multiple doses.

“It can address a whole bunch of features” associated with DNA editing, said Bolno, in a recent interview with BioPharma Dive.

Wave is one of only two companies, along with privately held Ascidian Therapeutics, with an RNA editing medicine in human trials. Its trial has therefore been closely watched by investors and analysts as a gauge of how well the technology might actually work.

Notably, while the two patients only received a single dose of Wave’s drug, the effects of treatment appeared more potent and durable than analysts had expected. The findings “provide [a] robust demonstration of ADAR RNA editing in humans” as well as “clinical validation” of Wave’s technology, wrote Leerink Partners analyst Joseph Schwartz in a note to clients.

“We view this as both a bar-clearing and, more importantly, enabling event for the ADAR space more broadly,” wrote William Blair analyst Myles Minter in a separate investor note.

The results lifted shares of Wave by more than 75% Wednesday morning, pushing its market value above $2 billion. Shares in Korro Bio and ProQR, two other companies investing in RNA editing, rose by even more.

Korro and another firm, the privately held Airna, are also working on RNA editing therapies for AATD. Korro has said it intends to ask regulators by the end of the year to start a trial.
17Oct
What to Buy and Where to Look

Key takeaways

Despite being Australia’s top-performing housing market over the last four decades, Melbourne has underperformed in recent years.

While other cities have seen double-digit growth, Melbourne’s prices have stagnated, driven largely by Victoria’s economic challenges.

Despite these challenges, Melbourne offers unique buying opportunities, with property prices significantly below replacement cost.

Today, Melbourne’s median house price is 41% cheaper than Sydney’s, the lowest relative price difference in over a decade.

Melbourne is poised to outperform other capital cities in the coming years due to strong population growth, economic recovery, and relative affordability. As interest rates fall, confidence is expected to return, leading to an uptick in property prices.

Now may be a prime time for investors to act before interest rates drop, which will increase competition from owner-occupiers. Buying below replacement cost in a market set for recovery could lead to significant returns as Melbourne’s property market rebounds.

While Melbourne has been Australia’s strongest-performing capital city housing market over the last four decades, it has underperformed over the last couple of years.

In fact, over the last 12 months, dwelling prices have basically been stagnant, while many other capital cities have enjoyed double-digit capital growth.

Several factors contribute to Melbourne’s residential property market’s underperformance, but the root cause is Victoria’s economic challenges.

Fact is…where the economy and jobs go, the property market follows.

Victoria has experienced significant economic setbacks, particularly evident in the net reduction of 7,606 businesses during the financial year 2022-23, according to the Australian Bureau of Statistics.

In stark contrast, Queensland saw a significant net increase in businesses, expanding by 11,031 in the same period.

This has not only been the aftermath of Victoria’s COVID-related lockdowns but also due to increased state government tax burdens on businesses, including payroll tax.

At the same time, many existing property investors are abandoning the Melbourne market, driven away by stricter residential tenancy legislation and higher land taxes.

Recent reforms in tenancy laws have tipped the balance heavily in favour of tenants, making it more challenging for landlords to manage their properties effectively.

In fact, many investors feel control is being taken away from them by government interference.

Additionally, the Victorian government’s decision to hike land taxes has only compounded the woes of property investors.

Yet despite the current struggles, there is a significant opportunity in Melbourne’s property market as property prices are generally considerably below replacement cost, creating a unique buying opportunity.

In fact, today, median house prices in Melbourne are approximately 41% cheaper than in Sydney.

This is the cheapest house Melbourne has been relative to Sydney in over a decade.

This situation in Melbourne today is similar to where Brisbane and Perth were three years ago.

Back then, both cities had experienced a period of underperformance, but those who bought then have since seen significant capital growth as these markets recovered.

This means that over the next couple of years, the Melbourne housing market will likely outperform other capital cities, driven by strong population growth, economic recovery, and relative affordability.

Confidence will return as interest rates fall over the next year or two, and buyers will return to the Melbourne property market.

However, affordability will still be an issue for many potential buyers, and buyers will only be able to pay up to the limit of what they can afford, so I would only invest in locations where wages are increasing faster than average and residents have multiple streams of income, not just wages.

This means investing in the more affluent inner-ring suburbs and the gentrifying middle-ring suburbs of Melbourne which will outperform the cheaper suburbs, where residents will still find it difficult to afford to buy a home.

Melbourne

The best-performing properties in Melbourne in 2025

1. Family-friendly homes

Price growth of established houses in Melbourne’s gentrifying suburbs will be underpinned by the ongoing trend of families seeking spacious homes with proximity to amenities, schools, parks, and transport links that continue to fuel demand for houses.

With Melbourne’s population growth back on the rise due to both domestic and international migration, family-oriented homes in established suburbs will maintain strong demand.

3-4 four-bedroom houses with larger land components, ideally with some potential for renovation or minor upgrades, will attract families and grow in value.

Middle-ring eastern suburbs such as Mount Waverly, Glen Waverley, Mitcham, Blackburn, and Ringwood are enjoying gentrification and infrastructure upgrades, and remain more affordable than inner suburbs, and therefore experiencing strong owner-occupier demand to push up prices as well as rental demand.

In the west, Essendon and Moonee Ponds are popular suburbs among families and professionals alike and provide easy access to the CBD, reputable schools, and ample lifestyle amenities.
17Oct
Which college football coaches have the hottest seats at the midseason mark?

It’s the midpoint of the college football season and usually, the coaching carousel is spinning much faster. It’s spinning slower this year for a few reasons. First, the past two seasons had much more turnover than initially expected; second, this is the first year of the 12-team College Football Playoff, which is extending the potential waiting time on some search options.

Things could get active at the Group of 5 level soon, though. Here’s our midseason assessment after talking to numerous industry sources about the FBS coaching landscape.

AAC

Mike Houston, East Carolina: 3-3 record this season

Before getting the ECU job, Houston went 37-6 at James Madison and won an FCS national title. He led the Pirates to two bowl games in his first four seasons but went 2-10 last year. His team just got whupped by 31 at Charlotte, now a rival program, and has lost by far its best player, cornerback Shavon Revel, to a season-ending knee injury. ECU still has Army and Navy, both Top 25 teams, plus 5-1 North Texas left. Tulsa, FAU and Temple are all very winnable. Getting to six wins might buy him more time, but his team could use a few wins down the stretch. Temperature check: Warm.

Mike Bloomgren, Rice: 2-4

This is a tough job. The former Stanford assistant got the Owls into a bowl game in his fifth year. Last season was his best: a 6-7  record that included snapping a seven-game losing streak to Houston. The Owls got off to a 1-4 start but just notched a nice, close win against UTSA for their first win against an FBS opponent. Getting bowl eligible looks doubtful, especially with only UAB seemingly looking like a likely win — and that one is on the road. Temperature check: A little warm.

Stan Drayton, Temple: 1-5

It’s been tough for Drayton to get much traction so far. The Owls are 2-16 in AAC play. The program wasn’t in great shape when Drayton took over for Rod Carey, whose teams only won two of his last 15 AAC games before he was fired. The Owls could really use a win at home against struggling Tulsa this weekend to get a little momentum going. Temperature check: Getting warmer.

Trent Dilfer, UAB: 1-5

The former NFL quarterback-turned-TV analyst had a lot of success building a powerhouse high school program in Nashville before getting the Blazers job over then-offensive coordinator Bryant Vincent, who not so coincidentally has done terrific in his debut season as the head man at the University of Louisiana-Monroe. That dynamic isn’t helping the situation for the first-time college coach. Vincent’s team blew out UAB 32-6 in early September. Dilfer went 4-8 last year and the Blazers are really struggling this year. Aside from a win over FCS Alcorn in the opener, this has been rough. They hung around against Arkansas and gave the Hogs a game, but the rest of the slate has been blowouts. They have home games against Tulsa, UConn and Rice. They need to win at least one of two of those to show some progress to quiet some of the critics since this was a fairly high-profile, outside-the-box hire. Temperature check: Getting hot.


Dilfer was a splashy, leap-of-faith hire for UAB, but the Blazers have struggled so far under his tenure. Photo: Wesley Hitt / Getty

ACC

Mack Brown, North Carolina: 3-4

The Tar Heels has been pretty good in Brown’s second stint with the program. In his second season back, they finished No. 18. The Tar Heels have won 17 games the past two seasons but it feels like the program has fallen off quite a bit this year. They’ve lost four in a row, including giving up 70 to JMU at home. The bright side: three of their remaining five opponents have losing records. Getting to six wins isn’t out of the question but there’s been increasing chatter that it might be time for a change from the 73-year-old Brown. Temperature check: Getting a lot warmer.

Big 12

Dave Aranda, Baylor: 2-4

The wild roller coaster ride that has been Aranda’s tenure in Waco, Texas has struggled to ramp back up. He went 2-7 in his first season and then, after overhauling his offensive staff, led Baylor to a 12-2 season, finishing No. 5. Since then, the Bears are 11-20. Baylor almost made a coaching change last winter but showed more patience with Aranda. There were more staff moves made that included Aranda taking over the defense this season. But after some good early signs, that side of the ball is struggling again. The issue has been that Aranda hasn’t recruited well enough or close to the level that Matt Rhule did. Aside from this weekend’s game at Texas Tech, none of the next five opponents have winning records. Temperature check: Hot.

go-deeper

GO DEEPER

Khan: Can Dave Aranda come back from Baylor’s collapse at Colorado?

Big Ten

Mike Locksley, Maryland: 3-3

A fast start has cooled quickly, with two double-digit losses including a dismal home showing where the Terrapins lost by 27 to a middling Northwestern team. Worse still, they’ll probably be underdogs in each of their last six games. A rebuilt O-line has struggled mightily, as has the secondary. Word out of College Park is that Locksley, who is so well-respected locally, has built up so much goodwill in his time there, especially having posted back-to-back eight-win seasons while in the much tougher side of the Big Ten and that’ll afford him a mulligan this year. In the previous 40 years, the Terps had only one stretch of three consecutive winning seasons until Locksley did it from 2021-2023. Temperature check: Lukewarm.

Ryan Walters, Purdue: 1-5

The former Colorado defensive back did outstanding work as Illinois’ defensive coordinator before getting this job. The Purdue offense sputtered in his debut season, managing 17 points or less six times in a 4-8 year. Walters fired OC Graham Harrell early this season and Purdue’s woes have continued. A 49-0 win over FCS Indiana State is the lone victory, but they did show signs of life, almost knocking off No. 23 Illinois on the road last weekend, 50-49, with freshman QB Ryan Browne in his first start. Four of their remaining six games are against top-16 teams.  The other two teams are .500 Northwestern and at Michigan. Can the Boilers notch at least one win to show some progress? Two years isn’t close to enough time, so I’d be very surprised if the Boilers made a move. After all, this is a program that hasn’t finished in the Top 25 once in the past 20 years and only had four winning seasons in the past 16 years. Temperature check: Getting a little warm.

Conference USA

Sonny Cumbie, Louisiana Tech: 2-4

He went 6-18 in his first two years. The Bulldogs lost their first three games against FBS teams this season. They hammered a bad MTSU team for their first FBS win of the season last week but weren’t able to build off of that. They lost in double-overtime to New Mexico State. Next up is another woeful team, UTEP. I thought 5-7 looked like where they were headed, but that was before losing to NMSU. Temperature check: Getting hotter.


I think Cumbie can buy himself another year with five wins. Photo: Jaylynn Nash / Imagn Images

MAC

Mike Neu, Ball State: 2-4

A former star QB for the Cardinals, Neu actually led Ball State to a Top 25 season in 2020, when the Cardinals finished No. 23. Neu followed that up with another bowl trip. They’ve tailed off some in the past two years and are off to a shaky start. They escaped with a two-point win against a hapless Kent State team on the road for their first FBS win. With the way their schedule sets up, getting more than three wins seems like a reach. He’s been the head coach for nine years and he’s the only one in school history that ever produced a Top 25 season, although Pete Lembo and Brady Hoke each did have double-digit win seasons. Still, this is a very tough place to win at. Temperature check: Warm.

Joe Moorhead, Akron: 1-6

One of the game’s better offensive minds has struggled to get any momentum here. He had back-to-back 2-10 seasons to start and looks like he might be headed to another one. Beyond Kent State, they won’t play another team with a losing record this season. Temperature check: Pretty warm.

Scot Loeffler, Bowling Green: 2-4

He’s coming off of his best season of his first five years, when the Falcons went 7-6. They are off to a slow start this fall but they’ve had three losses by a touchdown or less, including against two ranked teams on the road — Penn State and Texas A&M. I think they’re good enough to rally for six wins but even if they don’t, it’s hard to think they can expect better than what they’ve had from Loeffler. Temperature check: Sort of warm.

Kenni Burns, Kent State: 0-6

He took over for Sean Lewis, who left to become an OC at Colorado. Lewis led Kent State to its first bowl win and had two seven-win seasons at a place that’s only had three winning seasons since 1987. Burns, a former Minnesota running back coach, won one game in his first season, and is still looking for his first win this season. Losing to FCS St. Francis still stings. Can they knock off Akron in late November to get a win? I think it’s pretty poor form to hire someone and only give him two seasons, but if there is only one win or less in each of Burns’ first two years, it wouldn’t be surprising if the school got itchy. Temperature check: Getting warm.

Mountain West

Tim Skipper, Fresno State: 3-3

A former Bulldogs middle linebacker, Skipper is a well-respected part of the Fresno family and stepped up after Jeff Tedford stepped down for health reasons. Fresno State got off to a 3-1 start before losing the past two games. The Bulldogs have a decent shot to become a bowl team. If Fresno can go on a big run in the second half of the season, maybe Skipper can keep this job. Temperature check: Warm.

Nate Dreiling, Utah State: 1-5

The 33-year-old interim is still looking for his first FBS win. They pounded FCS Robert Morris in the opener and were then blasted in their next five games. Temperature check: They’ll be starting over this winter.

SEC

Sam Pittman, Arkansas: 4-2

After going 4-8 last season, Pittman’s seat was hot coming into this year, but he might be coaching his way to another. The Razorbacks won at Auburn and have a nice win against Tennessee their last time out. They still have 1-5 Mississippi State ahead and 2-3 Louisiana Tech. They may also be capable of knocking off LSU with the Tigers coming off the comeback win against Ole Miss last week. Barring a collapse, I think he’ll earn more time, unless the school is convinced it has a big upgrade waiting in the wings. Temperature check: Hot but cooling off a bit.

Billy Napier, Florida: 3-3

Florida doesn’t have a lot of patience with football coaches. The Gators fired Dan Mullen, who’d won 29 games in his first three seasons but got the axe after going 5-6. Jim McElwain won 19 games in his first two seasons and then went 3-4 and got fired. Will Muschamp got four years. Ron Zook didn’t even get three. Napier went 11-14 his first two years after an impressive run at Louisiana. This season has been a mixed bag. The Gators got pounded by Miami in the opener in The Swamp but the team is still battling for Napier. That’s been a big plus, in addition to the tricky timeline now with CFP candidates potentially in play.

There’s been a ton of dysfunction around the university, all the way up to the university president fleeing.

The good news: the Gators thumped Mississippi State in Starkville, Miss., beat UCF by double-digits and almost upset Tennessee in Knoxville before losing in overtime. They have four top-20 opponents left, including two in the top five, vs. Georgia and at Texas. The only team with a losing record remaining is their road trip to 1-5 FSU. They just lost starting QB Graham Mertz for the rest of the season. Can true freshman DJ Lagway spark a strong second half to get Florida to 6-6? If they win this weekend against Kentucky, don’t rule it out. Temperature check: Toasty.

go-deeper

GO DEEPER

Billy Napier beware: Florida has not historically been patient in rebuilds

Sun Belt

Shawn Clark, Appalachian State: 2-4

The former App State offensive lineman is well thought of in the Mountaineer community and he has three seasons with at least nine wins in his first four years. This year has been messy. They’ve lost three in a row, all by double digits and by giving up a ton of points. Just getting to five wins (the game against Liberty was canceled last month) looks dicey. And Appalachian State is not used to losing. Temperature check: Getting warm.

Butch Jones, Arkansas State: 3-3

Under Jones, the Red Wolves have gone from two wins to three wins to six and bowl game last year. I think they should get bowl eligible again. Their next two games are against Southern Miss and Troy, both 1-5 teams. They also have two games against two-win teams, so 6-6 feels like the floor, with seven wins seemingly realistic.
Temperature check: A little warm.

Will Hall, Southern Miss: 1-5

The son of a Mississippi high school legend, Hall, a very successful Division II coach, seemed like an excellent choice when he got this job four years ago. After a solid season season where the Golden Eagles went 7-6 and won a bowl game, they have backslid quite a bit. They went 3-9 last year and are really struggling now. All five losses have been by double-digits. They still have to go to JMU and Texas State. The final two games of the season are against two-win South Alabama and one-win Troy on the road. Temperature check: Very hot.

(Top illustration: Dan Goldfarb / The Athletic; Photos: Adam Davis, James Gilbert, Grant Halverson / Getty)
17Oct
Google’s Extension-Killing Manifest V3 Rollout Is Stepping Up, and It’s Time to Jump Ship

Google Chrome is rolling out its long-awaited Manifest V3 update and removing several of your favorite browser extensions with it.



The writing’s on the wall: It’s time to leave Google Chrome.



Why Google Chrome Is Removing Browser Extensions

Google is officially moving to Manifest V3, its updated Chrome extension specification. Manifest V2 extensions used an API feature called Web Request to monitor traffic, allowing them to block certain web requests. This functionality is central to how certain browser extensions operate, like ad blockers.

Now, Manifest V3 alters the Web Request API, moving that functionality to a new API called Declarative Net Request. It also restricts some of the old API’s previous functionality, which means browser extensions can no longer function as before.

According to Google, Manifest V3 will help to bolster the “security, privacy, performance and trustworthiness of the extension ecosystem as a whole.” But what that means in practical terms is that the leading ad-blocking extension, uBlock Origin, among others, will stop working on Google Chrome.


Check Which Chrome Extensions Are Being Removed From Chrome

uBlock Origin is the largest affected app—and one of the reasons many folks are jumping ship from Google Chrome. But there are numerous other apps set for removal.

To check the list, head to chrome://extensions in your address bar, then scroll down—you’ll see which of your installed Chrome extensions are set for removal.

It’s Time to Leave Google Chrome Behind

The Manifest V3 update has been on the cards since early 2024, with Google first announcing it on its Chromium Blog. Many folks have already jumped ship to other browsers, like Mozilla Firefox—which still supports the Web Request API and the associated apps.

Interestingly, a Google spokesperson told The Verge that some 93 percent of Chrome extensions are already Manifest V3-compliant. In addition, there is a Manifest V3-compliant version of uBlock Origin—that’s uBlock Origin Lite—but it isn’t as powerful as the original.


In addition, some Chromium-based browsers have said they’ll continue to support V2 Manifest apps for as long as possible. For example, Brave Browser CEO Brendan Eich previously tweeted about support, but that was back in 2022.

Whether Brave and other Chromium-based browsers manage to keep Manifest V2 extensions up and running remains to be seen.
17Oct
A caring mind creates unique houses from recycled architectural debris

Egret Garden, a unique residence built by Liao Quanfu from recycled materials like centuries-old bricks, tiles, and stone, stands as a testament to the harmony between tradition and sustainability. In this episode of “Housed in Tradition,” CGTN’s Qi Jie, alongside eco-construction expert Li Wei, explores how this extraordinary home reflects both environmental responsibility and creative design in suburban Guanghan City in Sichuan Province. Through thoughtful renovation, Egret Garden preserves the past while embracing a greener, more innovative future, offering a peaceful retreat that beautifully blends nature, history, and modern living.